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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T13148 | CHK-IN-1 | Chk | |
CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity. | |||
T10791 | CHK1-IN-3 | Chk | |
CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM). | |||
T10792 | CHK1-IN-4 | Chk | |
CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity. | |||
T10790 | CHK1-IN-2 | Chk | |
CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM). | |||
T37098 | Chk1-IN-5 | Chk1-IN-5 | |
Chk1-IN-5 is a highly effective inhibitor of checkpoint kinase 1 (Chk1), which hinders the phosphorylation of Chk1 and effectively suppresses tumor growth in a colon cancer xenograft model[1]. | |||
T40091 | Chk1-IN-6 | Chk1-IN-6 | |
Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate. | |||
T80132 | CBP501 Affinity Peptide | ||
CBP501 Affinity Peptide, a Chk kinase inhibitor, disrupts G2 arrest triggered by DNA-damaging agents and is utilized in cancer research [1]. | |||
T79874 | CHK-336 | ||
CHK-336 (Example 1), an orally active LDHA inhibitor (IC50 <1 nM), suppresses lactate production in mouse hepatocytes and is applicable in hyperoxaluria research [1]. | |||
T82393 | FLT3/CHK1-IN-1 | ||
Compound 18, also known as FLT3/CHK-IN-1, is a dual inhibitor targeting FLT3 and CHK1, exhibiting over 1700-fold selectivity towards c-KIT and significantly diminishing hERG affinity, with an IC50 of 58.4 μM. It demonstr... |